RAB4B Antibody (PACO29336)
- SKU:
- PACO29336
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RAB4B Antibody (PACO29336)
The Rab4B Polyclonal Antibody (PAC029336) is a valuable tool for researchers studying Rab4B, a member of the Rab family of small GTPases that play a critical role in regulating intracellular membrane trafficking. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Rab4B protein, this antibody enables researchers to detect and analyze Rab4B expression in various cell types, making it an ideal choice for studies in cell biology and molecular signaling pathways.Rab4B is involved in the endocytic pathway and is known to regulate the recycling of membrane proteins from early endosomes back to the plasma membrane.
Its dysfunction has been implicated in various diseases, including cancer and neurodegenerative disorders. Therefore, understanding the role of Rab4B in intracellular trafficking and membrane dynamics is crucial for unraveling the pathogenesis of these conditions and developing targeted therapies.Overall, the Rab4B Polyclonal Antibody is a reliable tool for researchers looking to investigate the function of Rab4B in cellular processes and disease mechanisms. Its high specificity and sensitivity make it a valuable asset in advancing our understanding of membrane trafficking and its implications in health and disease.
| Antibody Name: | RAB4B Antibody (PACO29336) |
| Antibody SKU: | PACO29336 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Ras-related protein Rab-4B protein (2-213AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: RAB4B antibody at 4µg/ml Lane 1: Mouse stomach tissue Lane 2: Mouse kidney tissue Lane 3: Mouse gonadal tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24, 28 kDa Observed band size: 24 kDa . |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO29336 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO29336 at dilution of 1:100. |
| Background: | Protein transport. Probably involved in vesicular traffic. |
| Synonyms: | Ras-related protein Rab-4B, RAB4B |
| UniProt Protein Function: | RAB4B: Protein transport. Probably involved in vesicular traffic. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric; G protein, monomeric, Rab; G proteinChromosomal Location of Human Ortholog: 19q13.2Cellular Component: perinuclear region of cytoplasm; recycling endosomeMolecular Function: protein bindingBiological Process: glucose import; regulation of endocytosis |
| UniProt Protein Details: | |
| NCBI Summary: | RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009] |
| UniProt Code: | P61018 |
| NCBI GenInfo Identifier: | 46577635 |
| NCBI Gene ID: | 53916 |
| NCBI Accession: | P61018.1 |
| UniProt Secondary Accession: | P61018,P22750, Q7Z514, Q9HBR6 |
| UniProt Related Accession: | P61018 |
| Molecular Weight: | 27,506 Da |
| NCBI Full Name: | Ras-related protein Rab-4B |
| NCBI Synonym Full Names: | RAB4B, member RAS oncogene family |
| NCBI Official Symbol: | RAB4BÂ Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | ras-related protein Rab-4B |
| UniProt Protein Name: | Ras-related protein Rab-4B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB4BÂ Â |
| UniProt Entry Name: | RAB4B_HUMAN |
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