The Rab43 Polyclonal Antibody (PACO11664) is a valuable tool for researchers studying Rab43, a small GTPase involved in intracellular protein trafficking and vesicle transport. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting Rab43 protein in human samples, making it an essential component in Western blot experiments.Rab43 is known to play a crucial role in the regulation of vesicular trafficking, particularly in the trans-Golgi network and endosomes. Its interaction with various effector proteins helps coordinate the movement of cargo vesicles to their target destinations within the cell. By targeting Rab43 with this antibody, researchers can gain insights into the mechanisms underlying intracellular transport and organelle dynamics.
Furthermore, Rab43 has been implicated in various cellular processes, including autophagy, phagocytosis, and cytokine secretion, suggesting its importance in immune responses and cell signaling pathways. Studying Rab43 using this antibody may offer new opportunities for understanding disease mechanisms and identifying potential therapeutic targets for disorders involving aberrant vesicle trafficking.Overall, the Rab43 Polyclonal Antibody (PACO11664) is a reliable tool for investigating the functions of Rab43 in cellular biology, offering researchers a deeper understanding of its role in health and disease.
RAB43, member RAS oncogene family;RAB43;ISY1;MGC90481;RAB11B;RAB41 ;
UniProt Protein Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
