The RAB41 Polyclonal Antibody (PACO17517) is a research tool designed for investigating the Rab41 protein, a member of the Ras-related small GTPase family involved in intracellular vesicle trafficking. This antibody, generated in rabbits, has high specificity and sensitivity for detecting Rab41 in human samples, making it a valuable tool for Western blot applications.Rab41 plays a key role in regulating vesicle transport within cells, particularly in the endolysosomal system. Dysregulation of Rab41 has been associated with various diseases, including neurological disorders and cancer. By targeting Rab41 with this antibody, researchers can better understand its function and its potential implications in disease development.
By studying Rab41, researchers can gain insights into cellular processes like protein sorting, membrane trafficking, and organelle dynamics. This antibody allows for the detection and analysis of Rab41 in different cell types, providing researchers with a versatile tool for exploring its biological functions and potential therapeutic targets.Overall, the RAB41 Polyclonal Antibody (PACO17517) is a valuable resource for research in cell biology, neuroscience, and cancer biology, offering researchers the ability to study the intricate mechanisms of intracellular vesicle trafficking and its implications in various diseases.
Antibody Name:
RAB41 Antibody (PACO17517)
Antibody SKU:
PACO17517
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human RAB41
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image is immunohistochemistry of paraffin-embedded Human renal cancer tissue using PACO17517(RAB41 Antibody) at dilution 1/100. (Original magnification: x200).
The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17517(RAB41 Antibody) at dilution 1/100. (Original magnification: x200).
Background:
This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex.
Synonyms:
Ras-related protein Rab-41
UniProt Protein Function:
RAB41: a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]Protein type: G protein, monomeric, Rab; G protein; G protein, monomericChromosomal Location of Human Ortholog: Xq13.1Cellular Component: Golgi apparatus; Golgi membraneMolecular Function: protein bindingBiological Process: intra-Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi; retrograde vesicle-mediated transport, Golgi to ER
UniProt Protein Details:
NCBI Summary:
This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]
