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RAB32 Antibody (PACO35498)

SKU:
PACO35498
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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RAB32 Antibody (PACO35498)

The Rab32 Polyclonal Antibody (PACO35498) is a valuable tool for researchers studying Rab32, a member of the Rab GTPase family involved in regulating intracellular membrane trafficking. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Rab32 in human samples, making it suitable for use in Western blot applications. By targeting Rab32, researchers can investigate its role in controlling vesicle transport and organelle dynamics within cells, providing insights into cellular processes such as autophagy, endocytosis, and secretion.

Rab32 is a key player in maintaining the structural and functional integrity of organelles such as mitochondria and lysosomes, highlighting its importance in cellular homeostasis and metabolism. Dysregulation of Rab32 has been implicated in various diseases, including neurodegenerative disorders and cancer, underscoring the need for further research into its molecular mechanisms and potential therapeutic implications. The Rab32 Polyclonal Antibody is an essential tool for unraveling the complex functions of Rab32 and its impact on cellular physiology and pathology.

Antibody Name:RAB32 Antibody (PACO35498)
Antibody SKU:PACO35498
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:Human, Mouse
Immunogen:Recombinant Human Ras-related protein Rab-32 protein (2-225AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: RAB32 antibody at 3µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 25 kDa. Observed band size: 25 kDa.
Background:Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).
Synonyms:Ras-related protein Rab-32, RAB32
UniProt Protein Function:RAB32: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 6q24.3

Cellular Component: early endosome; melanosome; membrane; mitochondrion; phagocytic vesicle; trans-Golgi network

Molecular Function:GTP-dependent protein binding; GTPase activity; protein binding

Biological Process: antigen processing and presentation

NCBI Summary:The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
UniProt Code:Q13637
NCBI GenInfo Identifier:2833245
NCBI Gene ID:10981
NCBI Accession:Q13637.3
UniProt Related Accession:Q13637
Molecular Weight:24,997 Da
NCBI Full Name:Ras-related protein Rab-32
NCBI Synonym Full Names:RAB32, member RAS oncogene family
NCBI Official Symbol:RAB32  
NCBI Protein Information:ras-related protein Rab-32
UniProt Protein Name:Ras-related protein Rab-32
Protein Family:Ras-related protein
UniProt Gene Name:RAB32  
UniProt Entry Name:RAB32_HUMAN
Antibodies
RAB32 Antibody (PACO11648)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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