The Rab18 Polyclonal Antibody (CAB2812) is a valuable tool for researchers studying the Rab18 protein, which plays a crucial role in regulating intracellular membrane trafficking and lipid droplet formation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in immunofluorescence and immunohistochemistry applications.Rab18 is a small GTPase protein that is involved in various cellular processes, including Golgi apparatus organization, lipid droplet formation, and autophagy. Dysregulation of Rab18 has been implicated in diseases such as obesity, diabetes, and neurodegenerative disorders, making it a promising target for therapeutic intervention.
The Rab18 Polyclonal Antibody enables researchers to detect and analyze Rab18 expression in different cell types and tissues, providing insights into its role in cellular physiology and disease progression. By understanding the function of Rab18, researchers can potentially uncover new therapeutic targets and develop novel treatment strategies for a range of diseases.
Product Name:
RAB18 Rabbit Polyclonal Antibody
SKU:
CAB2812
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RAB18 (NP_067075.1).
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
22931
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RAB18 antibody (CAB2812) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
