The R-Spondin 3 Polyclonal Antibody (CAB8389) is a valuable tool for researchers studying the R-Spondin 3 protein, which plays a crucial role in the Wnt signaling pathway. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the R-Spondin 3 protein, this antibody allows for the detection and analysis of this important molecule in various cell types.R-Spondin 3 is known for its ability to enhance Wnt signaling, which in turn regulates cell proliferation, differentiation, and tissue homeostasis. Dysregulation of the Wnt pathway, including aberrant R-Spondin 3 expression, has been implicated in various diseases, including cancer and developmental disorders.
By studying the function of R-Spondin 3 using this polyclonal antibody, researchers can gain valuable insights into the role of this protein in normal physiology and disease states.Overall, the R-Spondin 3 Polyclonal Antibody is a valuable tool for investigating the function of R-Spondin 3 in various biological processes, making it ideal for studies in developmental biology, cancer research, and regenerative medicine. By understanding the role of R-Spondin 3, researchers may uncover new therapeutic targets and strategies for treating a range of diseases.
Product Name:
RSPO3 Rabbit Polyclonal Antibody
SKU:
CAB8389
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RSPO3 (NP_116173.2).
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.
Purification Method:
Affinity purification
Gene ID:
84870
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RSPO3 antibody (CAB8389) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
