The QPRT Polyclonal Antibody (CAB14349) is specifically designed for research involving QPRT, a key enzyme in the tryptophan metabolism pathway with implications in immune regulation and neurodegenerative diseases. This antibody, produced in rabbits, is highly sensitive to human samples and has been validated for use in Western blot applications. It binds specifically to the QPRT protein, allowing for the accurate detection and analysis of QPRT levels in various cell types.QPRT is a crucial enzyme involved in the production of nicotinamide adenine dinucleotide (NAD+), a molecule essential for cellular energy production and DNA repair.
Dysregulation of QPRT has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as immune dysfunction. Understanding the role of QPRT in these pathways is essential for developing targeted therapies for these conditions.Researchers interested in studying the role of QPRT in immune regulation, neurodegenerative diseases, and metabolic disorders will find the QPRT Polyclonal Antibody (CAB14349) to be a valuable tool for their research. Its high reactivity and specificity make it ideal for investigating the expression and function of QPRT in various experimental settings.
Product Name:
QPRT Rabbit Polyclonal Antibody
SKU:
CAB14349
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human QPRT (NP_055113.2).
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23475
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using QPRT Rabbit pAb (CAB14349) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
