The QDPR Polyclonal Antibody (CAB5733) is a valuable tool for researchers studying the enzyme QDPR, which plays a crucial role in the production of tetrahydrobiopterin (BH4), a cofactor essential for neurotransmitter synthesis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting QDPR protein in human samples, making it ideal for use in Western blot applications.QDPR is involved in the maintenance of BH4 levels, which are necessary for the synthesis of neurotransmitters like dopamine, serotonin, and norepinephrine. Dysregulation of QDPR activity has been linked to various neurological disorders, including Parkinson's disease and depression.
By targeting QDPR, researchers can gain insights into the underlying mechanisms of these diseases and potentially develop novel therapeutic strategies.The QDPR Polyclonal Antibody is a valuable tool for investigating the role of QDPR in neurological disorders and exploring its potential as a therapeutic target. Its high specificity, sensitivity, and reliability make it a valuable asset for research in neuroscience, biochemistry, and pharmacology.
Product Name:
QDPR Rabbit Polyclonal Antibody
SKU:
CAB5733
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human QDPR (NP_000311.2).
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.
Purification Method:
Affinity purification
Gene ID:
5860
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using QDPR antibody (CAB5733) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
