The PYCR1 Polyclonal Antibody (CAB6959) is a valuable tool for researchers studying PYCR1, an enzyme involved in proline biosynthesis and cell metabolism. This antibody, produced in rabbits, shows high specificity and sensitivity for detecting PYCR1 in human samples, making it suitable for Western blot applications. By binding to the PYCR1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies related to metabolism, cancer, and cell growth.PYCR1 is a key enzyme in the proline biosynthesis pathway, playing a crucial role in various cellular processes such as collagen production, oxidative stress response, and cell proliferation.
Dysregulation of PYCR1 has been implicated in diseases like cancer, metabolic disorders, and neurodegenerative diseases, highlighting the importance of studying its function and regulation. The PYCR1 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of PYCR1 in health and disease, offering insights that may lead to the development of new therapeutic strategies.
Product Name:
PYCR1 Rabbit Polyclonal Antibody
SKU:
CAB6959
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-319 of human PYCR1 (NP_008838.2).
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5831
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PYCR1 antibody (CAB6959) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
