ASC/TMS1 Rabbit Polyclonal Antibody (CAB1170)
- SKU:
- CAB1170
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | ASC/TMS1 Rabbit Polyclonal Antibody |
SKU: | CAB1170 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-195 of human ASC/TMS1 (NP_037390.2). |
Sequence: | LDLT DKLV SFYL ETYG AELT ANVL RDMG LQEM AGQL QAAT HQGS GAAP AGIQ APPQ SAAK PGLH FIDQ HRAA LIAR VTNV EWLL DALY GKVL TDEQ YQAV RAEP TNPS KMRK LFSF TPAW NWTC KDLL LQAL RESQ SYLV EDLE RS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | ASC; TMS; TMS1; CARD5; TMS-1; ASC/TMS1 |
Positive Sample: | Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus. |
Calculated MW: | 22kDa |
Observed MW: | 15-19kDa/20kDa |
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 29108 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |