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Purified Anti-Human/Monkey CD154/CD40L Antibody [5C8] (AGEL1604)

SKU:
AGEL1604
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
NHP - Monkey
Applications:
FC
€149 - €329
Frequently bought together:

Description

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Purified Anti-Human/Monkey CD154/CD40L Antibody [5C8]

The Purified Human Monkey CD154 Monoclonal Antibody (5C8) (AGEL1604) is a valuable tool for researchers studying the CD154 protein, also known as CD40 ligand. This monoclonal antibody, produced for its high specificity and affinity, is suitable for various applications, including immunohistochemistry, flow cytometry, and ELISA.CD154 is a key molecule involved in immune responses, particularly in the activation of antigen-presenting cells and regulation of T cell-dependent immune reactions. Dysregulation of CD154 function has been implicated in autoimmune diseases, transplant rejection, and inflammatory disorders. Therefore, reliable reagents like the Purified Human Monkey CD154 Monoclonal Antibody (5C8) (AGEL1604) are essential for investigating the role of CD154 in these conditions.

This monoclonal antibody has been rigorously tested and validated for its performance with human and monkey samples, ensuring accurate and reproducible results in experimental settings. With its ability to specifically target the CD154 protein, researchers can confidently detect and analyze CD154 expression in different cell types, advancing studies in immunology, autoimmunity, and transplant biology.Overall, the Purified Human Monkey CD154 Monoclonal Antibody (5C8) (AGEL1604) is a sophisticated research tool that provides a deeper understanding of CD154 biology and its implications in immune-related diseases. By utilizing this antibody, researchers can explore new avenues for therapeutic interventions and improve patient outcomes in various clinical contexts.

Product Title:Purified Anti-Human/Monkey CD154/CD40L Antibody [5C8]
SKU:AGEL1604
Size:25µg, 100µg
Clone No:5C8
Synonyms:CD40L; gp39; TRAP; T-BAM; TNFSF5;
Host Species:Mouse
Reactivity:Human;Monkey
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P29965
Gene ID:959
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD154 (CD40 ligand) is also known as CD40L, gp39, TRAP and T-BAM. CD40 ligand is a 32-39 kD type II transmembrane glycoprotein. It is a member of the TNF superfamily and is expressed on activated T cells. It has been reported to be important for B cell costimulation following binding of its receptor, CD40. Additionally, binding of CD40L to CD40 on B cells promotes the secretion of immunoglobulin and Ig isotype switching. CD40L is also involved in the regulation of cytokine production by T cells.

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