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Purified Anti-Human CD28 Antibody [CD28.2] (AGEL2369)

SKU:
AGEL2369
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
CD28.2
Conjugation:
Unconjugated
$119 - $143
Frequently bought together:

Description

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Purified Anti-Human CD28 Antibody [CD28.2]

The Purified Anti-Human CD28 Antibody (CD28-2) offered by Assay Genie is a potent tool for researchers investigating the CD28 cell surface receptor. This antibody is specifically designed for use in immunology and cancer research studies where the CD28 molecule plays a crucial role in T cell activation and immune responses.Raised in rabbits for high reactivity and specificity, the Purified Anti-Human CD28 Antibody (CD28-2) is validated for various applications, including Western blot analysis and immunohistochemistry. By targeting the CD28 protein, this antibody enables precise detection and analysis of CD28 expression in different cell types, providing valuable insights into immune system regulation and cellular signaling pathways.CD28 is a key co-stimulatory molecule essential for T cell activation, cytokine production, and immune response modulation.

Its involvement in regulating T cell activation and differentiation makes it a critical target for research into autoimmune diseases, infectious diseases, and cancer immunotherapy. Understanding the intricate mechanisms of CD28 function is vital for developing novel treatments and immunotherapies aimed at manipulating the immune response for therapeutic benefit.With its proven efficacy and reliability, the Purified Anti-Human CD28 Antibody (CD28-2) from Assay Genie is a valuable addition to any research project focused on unraveling the complex interplay between the immune system and disease pathology. Trust in this high-quality antibody to enhance your research outcomes and drive progress in the fields of immunology and oncology.

Product Title:Purified Anti-Human CD28 Antibody [CD28.2]
SKU:AGEL2369
Size:25µg, 100µg
Clone No:CD28.2
Synonyms:PAS2;MNS;HGpMiX;GYPA;GPSAT;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P10747
Gene ID:940
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

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