The PURB Polyclonal Antibody (CAB18166) is a high-quality antibody designed for research involving the PURB protein, a key regulator of gene expression and RNA processing. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.The PURB protein, also known as purine-rich element-binding protein B, plays a crucial role in controlling gene expression at the post-transcriptional level. It is involved in the regulation of mRNA stability and translation, making it an important player in cellular processes such as cell growth, differentiation, and apoptosis.
Research on the PURB protein is essential for understanding its function in different biological contexts and its potential implications in diseases like cancer and neurodegenerative disorders.With its specificity and reliability, the PURB Polyclonal Antibody (CAB18166) allows for accurate detection and analysis of the PURB protein in various cell types and tissues. This antibody is a valuable tool for researchers in molecular biology, cell biology, and genetics who are interested in studying the role of the PURB protein in health and disease.
Product Name:
PURB Rabbit Polyclonal Antibody
SKU:
CAB18166
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 213-312 of human PURB (NP_150093.1).
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
Purification Method:
Affinity purification
Gene ID:
5814
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PURB Rabbit pAb (CAB18166) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
