The Pumilio Homolog 1 Polyclonal Antibody (CAB6108) is a key tool for researchers studying the Pumilio homolog 1 protein, a conserved RNA-binding protein that plays a crucial role in post-transcriptional regulation of gene expression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.Pumilio homolog 1 is known to be involved in a variety of biological processes, including embryonic development, cell cycle progression, and stem cell maintenance.
Its dysregulation has been linked to various diseases, such as cancer, neurological disorders, and infertility. By utilizing the CAB6108 antibody, researchers can explore the functions and mechanisms of Pumilio homolog 1 in different cell types and tissues, paving the way for potential therapeutic interventions in related conditions.
Product Name:
Pumilio 1 Rabbit Polyclonal Antibody
SKU:
CAB6108
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Pumilio 1 (NP_055491.1).
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
9698
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Pumilio 1 antibody (CAB6108) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 15s.
