PTRF Rabbit Polyclonal Antibody (CAB18331)
- SKU:
- CAB18331
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PTRF Rabbit Polyclonal Antibody |
SKU: | CAB18331 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-280 of human PTRF (NP_036364.2). |
Sequence: | ELSS DEAV EVEE VIEE SRAE RIKR SGLR RVDD FKKA FSKE KMEK TKVR TREN LEKT RLKT KENL EKTR HTLE KRMN KLGT R |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CGL4; PTRF; CAVIN; FKSG13; cavin-1 |
Positive Sample: | HT-1080,HeLa,A-549,Mouse stomach,Mouse lung,Mouse heart,Rat heart |
Cellular Localization: | Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Nucleus, caveola, cytosol. |
Calculated MW: | 43kDa |
Observed MW: | 55kDa |
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Purification Method: | Affinity purification |
Gene ID: | 284119 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |