The PTPRU Polyclonal Antibody (CAB8475) is a valuable tool for researchers studying PTPRU, a protein tyrosine phosphatase receptor type U involved in cell signaling and regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding to the PTPRU protein, this antibody enables accurate detection and analysis in a variety of cell types, facilitating research in the fields of cell biology and signal transduction.PTPRU is known to play a crucial role in mediating cellular processes such as cell growth, differentiation, and immune response regulation.
Dysregulation of PTPRU has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune conditions. Investigating the function and activity of PTPRU can provide valuable insights into disease mechanisms and potential therapeutic targets.Overall, the PTPRU Polyclonal Antibody (CAB8475) serves as a reliable tool for researchers aiming to unravel the molecular mechanisms underlying PTPRU function and its implications in disease pathology. Its versatility and high performance make it an essential component in studies focused on understanding cell signaling pathways and developing targeted therapies.
Product Name:
PTPRU Rabbit Polyclonal Antibody
SKU:
CAB8475
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTPRU (NP_005695.3).
Cell junction, Cell membrane, Single-pass type I membrane protein.
Calculated MW:
162kDa
Observed MW:
100kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
Purification Method:
Affinity purification
Gene ID:
10076
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain cells, using PTPRU antibody (CAB8475) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
