The PTPRR Polyclonal Antibody (CAB12246) is a valuable tool for researchers studying PTPRR, a protein tyrosine phosphatase receptor implicated in cellular signaling pathways. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blotting and immunofluorescence applications.PTPRR, also known as protein tyrosine phosphatase type IVA member 2, plays a crucial role in regulating cell growth, differentiation, and survival through dephosphorylation of target molecules.
Dysregulation of PTPRR has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in cellular function.By utilizing the PTPRR Polyclonal Antibody, researchers can effectively study the expression and localization of PTPRR in different cell types, leading to a better understanding of its role in disease pathogenesis. This antibody is a valuable tool for advancing research in the fields of oncology, neuroscience, and cell biology.
Product Name:
PTPRR Rabbit Polyclonal Antibody
SKU:
CAB12246
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-227 of human PTPRR (NP_002840.2).
Cell membrane, Cytoplasm, Single-pass type I membrane protein, perinuclear region, perinuclear region.
Calculated MW:
74kDa
Observed MW:
50kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12.
Purification Method:
Affinity purification
Gene ID:
5801
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTPRR Rabbit pAb (CAB12246) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
