The PTPRO Polyclonal Antibody (CAB6958) is a valuable tool for researchers studying PTPRO, a protein tyrosine phosphatase receptor involved in regulating cell signaling pathways. This antibody, generated in rabbits, is specifically designed to detect PTPRO in human samples and has been validated for use in Western blot applications. By targeting the PTPRO protein, this antibody allows for the precise detection and analysis of PTPRO expression in various cell types, making it ideal for investigations in the fields of cell biology and cancer research.
PTPRO plays a crucial role in modulating cellular processes such as cell growth, differentiation, and apoptosis through its regulation of protein phosphorylation. Dysregulation of PTPRO expression has been linked to various diseases, including cancer and autoimmune disorders, highlighting the importance of studying this protein in disease pathogenesis. By understanding the function of PTPRO, researchers can uncover potential therapeutic targets and develop innovative treatments for these debilitating conditions.
Product Name:
PTPRO Rabbit Polyclonal Antibody
SKU:
CAB6958
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human PTPRO (NP_109592.1).
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
Purification Method:
Affinity purification
Gene ID:
5800
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse kidney, using PTPRO antibody (CAB6958) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
