The PTPRN2 Polyclonal Antibody (CAB14774) is a valuable tool for researchers studying PTPRN2, a protein tyrosine phosphatase involved in insulin secretion and diabetes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to PTPRN2, allowing for accurate detection and analysis in a variety of cell types, making it ideal for studies in endocrinology and metabolic disorders.PTPRN2, also known as islet cell antigen-related protein, plays a critical role in insulin exocytosis and regulation of blood glucose levels.
Dysregulation of PTPRN2 has been linked to diabetes and other metabolic diseases, making it a promising target for therapeutic interventions. By understanding the function and regulation of PTPRN2, researchers can uncover new insights into the pathogenesis of these conditions and potentially identify novel treatment strategies.
Product Name:
PTPRN2 Rabbit Polyclonal Antibody
SKU:
CAB14774
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human PTPRN2 (NP_570858.2).
Cytoplasmic vesicle, Single-pass type I membrane protein, secretory vesicle, secretory vesicle membrane, synaptic vesicle membrane.
Calculated MW:
111kDa
Observed MW:
111kDa
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5799
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTPRN2 Rabbit pAb (CAB14774) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
