| UniProt Protein Function: | PTPRM: a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported.Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; Membrane protein, integral; Phosphatase; EC 3.1.3.48Chromosomal Location of Human Ortholog: 18p11.2Cellular Component: cell-cell adherens junction; integral to plasma membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; intercellular junctionMolecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activityBiological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; homophilic cell adhesion; protein amino acid dephosphorylation; positive regulation of vasodilation; signal transduction; neurite development; retinal ganglion cell axon guidance |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28827 |
| NCBI GenInfo Identifier: | 157419152 |
| NCBI Gene ID: | 5797 |
| NCBI Accession: | NP_001098714.1 |
| UniProt Secondary Accession: | P28827,A7MBN1, D3DUH8, J3QL11 |
| UniProt Related Accession: | P28827 |
| Molecular Weight: | 163,682 Da |
| NCBI Full Name: | receptor-type tyrosine-protein phosphatase mu isoform 1 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, M |
| NCBI Official Symbol: | PTPRMÂ Â |
| NCBI Official Synonym Symbols: | RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MUÂ Â |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase mu; protein tyrosine phosphatase mu; protein-tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase mu |
| UniProt Synonym Protein Names: | |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRMÂ Â |
| UniProt Entry Name: | PTPRM_HUMAN |
