The PTPRK Polyclonal Antibody (CAB14773) is a valuable tool for researchers studying the protein tyrosine phosphatase receptor kappa (PTPRK), a cell surface molecule known to play a crucial role in cellular signaling and regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications.PTPRK, also known as protein tyrosine phosphatase kappa, is involved in various cellular processes, including cell growth, differentiation, and adhesion. Its dysregulation has been linked to several diseases, including cancer, making it a potential target for therapeutic interventions.
The PTPRK Polyclonal Antibody binds specifically to the PTPRK protein, enabling the detection and analysis of its expression in different cell types.Researchers in the fields of cancer biology, cell signaling, and molecular biology will find this antibody particularly useful for investigating the role of PTPRK in disease development and progression. By understanding the functions of PTPRK, scientists may uncover new insights into disease mechanisms and potentially identify novel therapeutic targets for the treatment of cancer and other related disorders.
Product Name:
PTPRK Rabbit Polyclonal Antibody
SKU:
CAB14773
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-750 of human PTPRK (NP_001129120.1).
Cell junction, Cell membrane, Single-pass type I membrane protein, adherens junction.
Calculated MW:
162kDa
Observed MW:
162kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
Purification Method:
Affinity purification
Gene ID:
5796
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse liver, using PTPRK Rabbit pAb (CAB14773) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
