PTPRK Rabbit Polyclonal Antibody (CAB14773)
- SKU:
- CAB14773
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PTPRK Rabbit Polyclonal Antibody |
SKU: | CAB14773 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-750 of human PTPRK (NP_001129120.1). |
Sequence: | EGVD ASLN ETAT TITV LLRP AQAK GAPI SAYQ IVVE ELHP HRTK REAG AMEC YQVP VTYQ NAMS GGAP YYFA AELP PGNL PEPA PFTV GDNR TYQG FWNP PLAP RKGY NIYF QAMS SVEK ETKT QCVR IATK AAAT EEPE VIPD PAKQ TDR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | R-PTP-kappa; PTPRK |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Single-pass type I membrane protein, adherens junction. |
Calculated MW: | 162kDa |
Observed MW: | 162kDa |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
Purification Method: | Affinity purification |
Gene ID: | 5796 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |