The PTPRE Polyclonal Antibody (CAB7209) is a valuable tool for researchers studying the protein tyrosine phosphatase receptor type E (PTPRE) in various cellular processes. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PTPRE protein, this antibody allows for the detection and analysis of PTPRE in different cell types, making it ideal for studies in cell signaling, cancer research, and immunology.PTPRE is a crucial enzyme involved in the regulation of cell signaling pathways through the dephosphorylation of target proteins.
Its dysregulation has been implicated in various diseases, including cancer and immune disorders. By understanding the role of PTPRE in these processes, researchers can potentially develop targeted therapies for these conditions.Overall, the PTPRE Polyclonal Antibody provides a reliable tool for studying the function of PTPRE in research fields such as cell biology, oncology, and immunology. Its specificity and sensitivity make it a valuable asset for scientists looking to unravel the complex mechanisms underlying disease pathogenesis.
Product Name:
PTPRE Rabbit Polyclonal Antibody
SKU:
CAB7209
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human PTPRE (NP_006495.1).
Cell membrane, Cytoplasm, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
81kDa
Observed MW:
81kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.
Purification Method:
Affinity purification
Gene ID:
5791
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTPRE Rabbit pAb (CAB7209) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
