The PTPRC Polyclonal Antibody (CAB2115) is a valuable tool for researchers studying PTPRC, a protein also known as CD45 that is expressed on the surface of immune cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the PTPRC protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in immunology and cancer research.PTPRC, or CD45, is a critical regulator of immune cell function, playing a key role in signaling pathways that control immune responses. Its involvement in immune cell activation and differentiation makes it a target of interest for understanding diseases such as cancer, autoimmune disorders, and infectious diseases.
By investigating the function of PTPRC, researchers can gain insights into potential therapeutic strategies that modulate immune responses in various disease contexts.Overall, the PTPRC Polyclonal Antibody (CAB2115) provides researchers with a reliable tool for studying the role of PTPRC in immune cell biology and disease pathogenesis. Its high specificity and reactivity make it a valuable asset for advancing our understanding of immune system function and developing novel treatment approaches for immune-related disorders.
Product Name:
CD45 Rabbit Polyclonal Antibody
SKU:
CAB2115
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 194-390 of human CD45 (NP_002829.3).
Membrane, Membrane raft, Single-pass type I membrane protein.
Calculated MW:
147kDa
Observed MW:
180-240kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Purification Method:
Affinity purification
Gene ID:
5788
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using CD45 Rabbit pAb (CAB2115) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
