CD45 Rabbit Polyclonal Antibody (CAB2115)
- SKU:
- CAB2115
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | CD45 Rabbit Polyclonal Antibody |
SKU: | CAB2115 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 194-390 of human CD45 (NP_002829.3). |
Sequence: | SDAY LNAS ETTT LSPS GSAV ISTT TIAT TPSK PTCD EKYA NITV DYLY NKET KLFT AKLN VNEN VECG NNTC TNNE VHNL TECK NASV SISH NSCT APDK TLIL DVPP GVEK FQLH DCTQ VEKA DTTI CLKW KNIE TFTC DTQN ITYR FQCG NMIF DNKE IKLE NLEP EHEY KCDS EILY NNHK FTNA SKII KTDF G |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Membrane raft, Single-pass type I membrane protein. |
Calculated MW: | 147kDa |
Observed MW: | 180-240kDa |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5788 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |