The PTPRA Polyclonal Antibody (CAB12318) is a valuable tool for researchers studying PTPRA, a protein tyrosine phosphatase receptor implicated in cell signaling and regulation. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the PTPRA protein, the antibody allows for detection and analysis in a variety of cell types, making it ideal for studies in signal transduction pathways and cancer research.PTPRA is known for its role in regulating cellular processes such as growth, differentiation, and apoptosis through dephosphorylation of target proteins.
Its involvement in signaling cascades makes it a key player in various physiological and pathological conditions. Research on PTPRA can provide insights into cancer progression, diabetes, and neurological disorders, offering potential targets for therapeutic interventions.With its high specificity and reliability, the PTPRA Polyclonal Antibody (CAB12318) is a valuable tool for investigating the function and regulation of PTPRA in cellular processes, paving the way for advancements in biomedical research and drug development.
Product Name:
PTPRA Rabbit Polyclonal Antibody
SKU:
CAB12318
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 175-295 of human PTPRA (NP_543030.1).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
Purification Method:
Affinity purification
Gene ID:
5786
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTPRA Rabbit pAb (CAB12318) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
