SHP1 Rabbit Polyclonal Antibody (CAB1446)
- SKU:
- CAB1446
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SHP1 Rabbit Polyclonal Antibody |
SKU: | CAB1446 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human SHP1 (NP_002822.2). |
Sequence: | LNCS DPTS ERWY HGHM SGGQ AETL LQAK GEPW TFLV RESL SQPG DFVL SVLS DQPK AGPG SPLR VTHI KVMC EGGR YTVG GLET FDSL TDLV EHFK KTGI EEAS GAFV YLRQ PYYA TRVN AADI ENRV LELN KKQE SEDT AKAG FWEE FESL QKQE VKNL HQRL EGQR PENK GKNR YKNI LPFD HSRV ILQG RDSN IPGS DYIN ANYI KNQL LGPD ENAK TYIA SQGC LEAT VNDF WQMA WQEN SRVI VMTT REVE KGRN KCVP YWPE VGMQ RAYG PYSV TNCG EHDT TEYK LRTL QVSP L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1 |
Positive Sample: | BT-474,MCF7,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 68kDa |
Observed MW: | 68kDa |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5777 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |