The PTPN22 Polyclonal Antibody (CAB1406) is a valuable tool for researchers studying the PTPN22 protein, a critical regulator of immune signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PTPN22 protein, it allows for precise detection and analysis in various cell types, making it an essential component in immunology and autoimmune disease research.
PTPN22 is known for its role in modulating immune responses by regulating T cell activation and cytokine production. Dysregulation of PTPN22 has been implicated in autoimmune disorders such as rheumatoid arthritis and lupus, making it a promising therapeutic target. By studying the function of PTPN22 using this polyclonal antibody, researchers can gain valuable insights into the underlying mechanisms of autoimmune diseases and potentially develop new treatment strategies.
Product Name:
PTPN22 Rabbit Polyclonal Antibody
SKU:
CAB1406
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PTPN22 (NP_036543.4).
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
26191
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTPN22 Rabbit pAb (CAB1406) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
