PTPN2 Rabbit Polyclonal Antibody (CAB1808)
- SKU:
- CAB1808
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PTPN2 Rabbit Polyclonal Antibody |
SKU: | CAB1808 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PTPN2 (NP_536348.1). |
Sequence: | MPTT IERE FEEL DTQR RWQP LYLE IRNE SHDY PHRV AKFP ENRN RNRY RDVS PYDH SRVK LQNA ENDY INAS LVDI EEAQ RSYI LTQG PLPN TCCH FWLM VWQQ KTKA VVML NRIV EKES VKCA QYWP TDDQ EMLF KETG FSVK LLSE DVKS YYTV HLLQ LENI NSGE TRTI SHFH YTTW PDFG VPES PASF LNFL FKVR ESGS LNPD HGPA VIHC SAGI GRSG TFSL VDTC LVLM EKGD DINI KQVL LNMR KYRM GLIQ TPDQ LRFS YMAI IEGA KCIK GDSS IQKR WKEL SKED LSPA FDHS PNKI MTEK YNGN RIGL EEEK LTGD RCTG LSSK MQDT MEEN SERP RLTD T |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; N2 |
Positive Sample: | SW480,BT-474,Jurkat,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Endoplasmic reticulum, Endoplasmic reticulum-Golgi intermediate compartment, Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | 45kDa |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5771 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |