PTPN13 Rabbit Polyclonal Antibody (CAB13005)
- SKU:
- CAB13005
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PTPN13 Rabbit Polyclonal Antibody |
SKU: | CAB13005 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1). |
Sequence: | QDEN YFKD ILSD NSGR EDSE NTFS PYQF KTSG PEKK PIPG IDVL SKKK IWAS SMDL LCTA DRDF SSGE TATY RRCH PEAV TVRT STTP RKKE ARYS DGSI ALDI FGPQ KMDP IYHT RELP TSSA ISSA LDRI RERQ KKLQ VLRE AMNV EEPV RRYK TYHG DVFS TSSE SPSI ISSE SDFR QVRR SEAS KRFE SSSG LPGV DETL SQGQ SQRP SRQY ETPF EGNL INQE IMLK RQEE ELMQ LQAK MALR QSR |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:2000 - 1:6000 IF/ICC,1:50 - 1:100 |
Synonyms: | PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS; PTPN13 |
Positive Sample: | Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, Nucleus, cytoskeleton, lamellipodium. |
Calculated MW: | 277kDa |
Observed MW: | 250kDa |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5783 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |