The PTPN13 Polyclonal Antibody (CAB13005) is a specialized research tool designed for studying the PTPN13 protein, a phosphatase that plays a key role in cellular signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it a reliable tool for Western blot experiments. By targeting the PTPN13 protein, researchers can investigate its function in various cell types and gain insights into its involvement in signaling cascades related to cancer and other diseases.PTPN13, also known as Fas-associated phosphatase-1 (FAP-1), is a crucial regulator of cell growth, survival, and differentiation.
Dysregulation of PTPN13 has been implicated in various human cancers and is therefore a promising therapeutic target for cancer treatment. By studying the role of PTPN13 in cellular signaling, researchers can uncover potential therapeutic strategies for targeting this phosphatase in cancer therapy. Overall, the PTPN13 Polyclonal Antibody is a valuable tool for researchers interested in elucidating the functions and regulatory mechanisms of the PTPN13 protein in disease states, ultimately contributing to the development of novel therapeutic interventions.
Product Name:
PTPN13 Rabbit Polyclonal Antibody
SKU:
CAB13005
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Purification Method:
Affinity purification
Gene ID:
5783
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse heart, using PTPN13 Rabbit pAb (CAB13005) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
