The PTPN11 Polyclonal Antibody (CAB2793) is a powerful tool for researchers studying PTPN11, a key protein involved in cell signaling pathways and regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PTPN11 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in cell biology and cancer studies.PTPN11, also known as protein tyrosine phosphatase, plays a crucial role in various cellular processes, including cell growth, differentiation, and survival.
Dysregulation of PTPN11 has been linked to several diseases, including various cancers and developmental disorders. By studying the function of PTPN11, researchers can gain insights into disease mechanisms and potentially uncover new therapeutic targets for treatment.Overall, the PTPN11 Polyclonal Antibody (CAB2793) is a valuable tool for researchers seeking to unravel the complexities of cell signaling and disease pathogenesis. Its specificity and reliability make it a key component in advancing our understanding of PTPN11 and its implications in human health.
Product Name:
SHP2 Rabbit Polyclonal Antibody
SKU:
CAB2793
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 514-593 of human SHP2 (NP_002825.3).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Purification Method:
Affinity purification
Gene ID:
5781
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SHP2 Rabbit pAb (CAB2793) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
