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[KO Validated] SHP2 Rabbit Polyclonal Antibody (CAB12486)

SKU:
CAB12486
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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  • KO Validated Antibodies 1 Anti-PTPN11 Antibody CAB12486KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] SHP2 Rabbit Polyclonal Antibody
SKU:CAB12486
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-460 of human SHP2 (NP_002825.3).
Sequence:MTSR RWFH PNIT GVEA ENLL LTRG VDGS FLAR PSKS NPGD FTLS VRRN GAVT HIKI QNTG DYYD LYGG EKFA TLAE LVQY YMEH HGQL KEKN GDVI ELKY PLNC ADPT SERW FHGH LSGK EAEK LLTE KGKH GSFL VRES QSHP GDFV LSVR TGDD KGES NDGK SKVT HVMI RCQE LKYD VGGG ERFD SLTD LVEH YKKN PMVE TLGT VLQL KQPL NTTR INAA EIES RVRE LSKL AETT DKVK QGFW EEFE TLQQ QECK LLYS RKEG QRQE NKNK NRYK NILP FDHT RVVL HDGD PNEP VSDY INAN IIMP EFET KCNN SKPK KSYI ATQG CLQN TVND FWRM VFQE NSRV IVMT TKEV ERGK SKCV KYWP DEYA LKEY GVMR VRNV KESA AHDY TLRE LKLS KVGQ GNTE RTVW QYHF RTWP DHGV PSDP GGVL DFLE EVHH KQES IMDA GPVV VHCS
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3; P2
Positive Sample:U-87MG,Jurkat,A-431,MCF-7,Mouse brain,Rat brain,Rat lung
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:68kDa
Observed MW:75kDa

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Purification Method:Affinity purification
Gene ID:5781
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and SHP2 knockout (KO) 293T cells, using [KO Validated] SHP2 Rabbit pAb (CAB12486) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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