The PPP2R4 Polyclonal Antibody (CAB11999) is a valuable tool for researchers studying PPP2R4, a regulatory subunit of the protein phosphatase 2A (PP2A) complex involved in cell signaling processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot experiments. It specifically targets the PPP2R4 protein, allowing for detailed analysis and detection in various cell types.PPP2R4 plays a critical role in the regulation of PP2A activity, which is essential for many cellular functions, including cell growth, division, and apoptosis. Dysregulation of PP2A has been associated with various diseases, such as cancer, neurodegenerative disorders, and cardiovascular conditions.
Thus, understanding the role of PPP2R4 in these processes is crucial for developing potential therapeutic interventions targeting PP2A signaling pathways.The PPP2R4 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complex mechanisms of PP2A regulation and its implications in health and disease. Its specificity and sensitivity make it an ideal choice for immunological and cancer research studies aimed at exploring the therapeutic potential of targeting PP2A-associated pathways.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
5524
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ser/thr-PP2A activator (PTPA) Rabbit pAb (CAB11999) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
