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Ser/thr-PP2A activator (PTPA) Rabbit Polyclonal Antibody (CAB11999)

SKU:
CAB11999
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Ser/thr-PP2A activator (PTPA) Rabbit Polyclonal Antibody
SKU:CAB11999
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 58-240 of human Ser/thr-PP2A activator (PTPA) (NP_821068.1).
Sequence:GVKG KKLT FEYR VSEM WNEV HEEK EQAA KQSV SCDE CIPL PRAG HCAP SEAI EKLV ALLN TLDR WIDE TPPV DQPS RFGN KAYR TWYA KLDE EAEN LVAT VVPT HLAA AVPE VAVY LKES VGNS TRID YGTG HEAA FAAF LCCL CKIG VLRV DDQI AIVF KVFN RYLE VMRK LQKT YRME PAG
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:PP2A; PR53; PPP2R4; Ser/thr-PP2A activator (PTPA)
Positive Sample:LO2,K-562,U-87MG,MCF7,Mouse brain,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:41kDa
Observed MW:40kDa

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification Method:Affinity purification
Gene ID:5524
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Ser/thr-PP2A activator (PTPA) Rabbit pAb (CAB11999) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.

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