The PTP4A2 Polyclonal Antibody (CAB15335) is a valuable tool for researchers studying PTP4A2, a protein tyrosine phosphatase implicated in various cellular processes, including cell proliferation, differentiation, and migration. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.PTP4A2, also known as protein tyrosine phosphatase type IVA member 2, is involved in the regulation of signaling pathways that control cell growth and survival, making it a key player in cancer development and progression.
Its dysregulation has been linked to various types of cancer, making it a promising target for therapeutic interventions.By targeting PTP4A2 with this polyclonal antibody, researchers can detect and analyze the protein in different cell types, allowing for a better understanding of its role in cancer biology. This antibody is ideal for studies in oncology and cell biology, providing valuable insights into the mechanisms underlying cancer and potential therapeutic strategies.
Product Name:
PTP4A2 Rabbit Polyclonal Antibody
SKU:
CAB15335
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-100 of human PTP4A2 (NP_536316.1).
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
Purification Method:
Affinity purification
Gene ID:
8073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTP4A2 Rabbit pAb (CAB15335) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
