The PTMA Polyclonal Antibody (PACO17243) is a valuable tool for researchers studying the PTMA protein, which is involved in various cellular processes such as cell cycle regulation, apoptosis, and gene expression. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for a range of research applications, including Western blotting.PTMA, also known as prothymosin alpha, is a versatile protein that has been implicated in cancer development, immune regulation, and DNA repair mechanisms. Its diverse functions make it a compelling target for investigations in oncology, immunology, and molecular biology.
By using the PTMA Polyclonal Antibody, researchers can detect and analyze PTMA expression in different cell types, aiding in the understanding of its role in various biological processes.The PTMA Polyclonal Antibody is an essential tool for researchers seeking to unravel the complexities of PTMA function and its implications in health and disease. Its high specificity and sensitivity make it a reliable reagent for exploring the biology of PTMA and its potential as a therapeutic target in cancer and other diseases.
Antibody Name:
PTMA Antibody (PACO17243)
Antibody SKU:
PACO17243
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17243(PTMA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17243(PTMA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Prothymosin α (PTMA) is a nuclear protein possessing a number of cellular functions including cell survival. PTMA is identified to be localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brai. PTMA inhibits the neuronal necrosis induced by serum-free starvation or ischemia-reperfusion stress, which causes a rapid internalization of GLUT1/4, leading a decrease in glucose uptake and cellular ATP levels. Extensive research on PTMA showed that it is of clinical significance and potential medical use as they may serve as a molecular marker for cancer prognosis and/or as therapeutic agents for treating immunodeficiencies, autoimmune diseases and malignancies.
Synonyms:
prothymosin, alpha
UniProt Protein Function:
PTMA: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Cell cycle regulation; Nuclear receptor co-regulator
