The PTK6 Polyclonal Antibody (CAB7497) is a valuable tool for researchers studying PTK6, a non-receptor protein tyrosine kinase involved in various cellular processes, including cell proliferation and differentiation. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the PTK6 protein, this antibody enables accurate detection and analysis in a range of cell types, making it ideal for investigations in cancer biology, signal transduction, and developmental biology.
PTK6, also known as breast tumor kinase (BRK), is a promising target for cancer therapy due to its involvement in promoting tumor growth and metastasis. Understanding the mechanisms by which PTK6 contributes to cancer progression is essential for developing targeted treatments that could disrupt its oncogenic signaling pathways. Research into PTK6 may lead to new insights into cancer biology and the development of novel therapies for cancer patients.
Product Name:
PTK6 Rabbit Polyclonal Antibody
SKU:
CAB7497
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 222-451 of human PTK6 (NP_005966.1).
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5753
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTK6 Rabbit pAb (CAB7497) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
