The PTK2B Polyclonal Antibody (CAB16045) is a valuable tool for researchers studying PTK2B, a protein tyrosine kinase implicated in cellular signaling and growth regulation. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By targeting the PTK2B protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in cell biology and cancer research.PTK2B, also known as focal adhesion kinase 2 (FAK2), plays a crucial role in cell adhesion, migration, and survival pathways.
Its involvement in cancer progression, angiogenesis, and metastasis highlights its potential as a therapeutic target for cancer treatment and drug development. By unraveling the signaling pathways and functions of PTK2B, researchers can gain valuable insights into the mechanisms driving cancer growth and metastasis, paving the way for the development of targeted therapies and precision medicine approaches.
Product Name:
PTK2B Rabbit Polyclonal Antibody
SKU:
CAB16045
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 780-1009 of human PTK2B (NP_004094.3).
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2185
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTK2B Rabbit pAb (CAB16045) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
