PTK2B Rabbit Polyclonal Antibody (CAB16045)
- SKU:
- CAB16045
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | PTK2B Rabbit Polyclonal Antibody |
SKU: | CAB16045 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 780-1009 of human PTK2B (NP_004094.3). |
Sequence: | REED FIQP SSRE EAQQ LWEA EKVK MRQI LDKQ QKQM VEDY QWLR QEEK SLDP MVYM NDKS PLTP EKEV GYLE FTGP PQKP PRLG AQSI QPTA NLDR TDDL VYLN VMEL VRAV LELK NELC QLPP EGYV VVVK NVGL TLRK LIGS VDDL LPSL PSSS RTEI EGTQ KLLN KDLA ELIN KMRL AQQN AVTS LSEE CKRQ MLTA SHTL AVDA KNLL DAVD QAKV LANL AHPP AE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK; PTK2B |
Positive Sample: | Raji,Mouse kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein, cell cortex, focal adhesion, lamellipodium, perinuclear region |
Calculated MW: | 116kDa |
Observed MW: | 116kDa |
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2185 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |