The PTHLH Polyclonal Antibody (CAB3183) is a valuable tool for research involving the parathyroid hormone-like hormone (PTHLH), a key regulator of calcium and phosphate homeostasis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.PTHLH is involved in a wide range of physiological processes, including bone development, cartilage growth, and tooth formation. Dysregulation of PTHLH signaling has been implicated in skeletal disorders, such as osteoporosis, as well as in cancer progression, particularly in breast and prostate cancers.
By targeting PTHLH with this antibody, researchers can study its expression and function in different cell types and tissues, advancing our understanding of its role in health and disease.Overall, the PTHLH Polyclonal Antibody (CAB3183) is a valuable tool for investigating the complex signaling pathways involving PTHLH and its potential as a therapeutic target in various medical conditions. Its specificity and reliability make it an essential component in studies focused on calcium metabolism, bone health, and cancer biology.
Product Name:
PTHLH Rabbit Polyclonal Antibody
SKU:
CAB3183
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-175 of human PTHLH (NP_945316.1).
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone.
Purification Method:
Affinity purification
Gene ID:
5744
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PTHLH Rabbit pAb (CAB3183) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
