The PTHLH Polyclonal Antibody (CAB1654) is a crucial tool for researchers studying parathyroid hormone-like hormone (PTHLH), a protein involved in a variety of physiological processes including bone development, calcium regulation, and cell proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting PTHLH in human samples, making it ideal for use in Western blot applications.PTHLH is known for its role in regulating calcium levels in the body, as well as its effects on cell growth and differentiation. Dysregulation of PTHLH has been linked to various diseases, making it a promising target for therapeutic interventions.
By enabling the detection and analysis of PTHLH in different cell types, this antibody provides valuable insight into the function and signaling pathways of PTHLH, making it a valuable tool for research in fields such as endocrinology, bone biology, and cancer research.With its ability to specifically bind to PTHLH, this polyclonal antibody offers researchers a valuable tool for investigating the role of PTHLH in health and disease. Its reliability and accuracy make it an essential component of any study seeking to understand the mechanisms underlying PTHLH-mediated physiological processes.
Product Name:
PTHLH Rabbit Polyclonal Antibody
SKU:
CAB1654
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-175 of human PTHLH (NP_945315.1).
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone.
Purification Method:
Affinity purification
Gene ID:
5744
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using PTHLH antibody (CAB1654) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
