The PTH Antibody (PACO34766) is a high-quality polyclonal antibody designed for research involving parathyroid hormone (PTH), a key regulator of calcium and phosphorus metabolism in the body. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.PTH is a crucial hormone produced by the parathyroid glands that helps regulate calcium levels in the blood, bone, and kidneys. Dysregulation of PTH can lead to disorders such as hyperparathyroidism or hypoparathyroidism, affecting bone health and mineral balance.
By targeting PTH with this antibody, researchers can study its expression and localization in various tissues, providing insights into its role in bone metabolism and mineral homeostasis.This PTH Antibody is an essential tool for studies in endocrinology, nephrology, and bone biology, shedding light on the molecular mechanisms underlying PTH action and its implications for diseases like osteoporosis, hypercalcemia, and renal disorders. Its specificity and reliability make it a valuable asset for researchers investigating the physiological and pathological roles of PTH in health and disease.
Antibody Name:
pth Antibody (PACO34766)
Antibody SKU:
PACO34766
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Peptidyl-tRNA hydrolase protein (1-194AA)
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death.
Synonyms:
Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29), pth
UniProt Protein Function:
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death.
UniProt Protein Details:
NCBI Summary:
Histidine 20 acts as the catalytic base during hydrolysis. [More information is available at EcoGene: EG10785]. Peptidyl-tRNA hydrolase is essential for growth in Escherichia coli. lysV, a lysine acceptor tRNA, was found to be a multicopy suppressor of a temperature sensitive pth mutant, indicating that the pth mutant phenotype is due to starvation for Lys-tRNA(Lys) . [More information is available at EcoCyc: EG10785].
