The PTGS2 Polyclonal Antibody (CAB1253) is a valuable tool for researchers investigating the role of PTGS2, also known as COX-2, in various biological processes. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples and has been validated for use in Western blot applications. By targeting the PTGS2 protein, this antibody enables the detection and analysis of PTGS2 expression in different cell types, making it suitable for studies in areas such as inflammation, cancer, and pain.PTGS2, a key enzyme involved in the production of prostaglandins, plays a crucial role in inflammatory responses and pain modulation.
Dysregulation of PTGS2 has been implicated in various diseases, including cancer, arthritis, and cardiovascular disorders, making it a promising therapeutic target. Understanding the expression and activity of PTGS2 is essential for developing treatments that target the inflammatory pathways mediated by this enzyme.Overall, the PTGS2 Polyclonal Antibody (CAB1253) offers researchers a reliable tool for investigating the functions of PTGS2 in different biological contexts, ultimately advancing our understanding of inflammation-related diseases and facilitating the development of targeted therapies.
Product Name:
Cox2 Rabbit Polyclonal Antibody
SKU:
CAB1253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 375-604 of COX2/PTGS2 (NP_000954.1).
Sequence:
PLLP DTFQ IHDQ KYNY QQFI YNNS ILLE HGIT QFVE SFTR QIAG RVAG GRNV PPAV QKVS QASI DQSR QMKY QSFN EYRK RFML KPYE SFEE LTGE KEMS AELE ALYG DIDA VELY PALL VEKP RPDA IFGE TMVE VGAP FSLK GLMG NVIC SPAY WKPS TFGG EVGF QIIN TASI QSLI CNNV KGCP FTSF SVPD PELI KTVT INAS SSRS GLDD INPT VLLK ERST EL
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Purification Method:
Affinity purification
Gene ID:
5743
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using COX2/PTGS2 Rabbit pAb (CAB1253) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
