PTGR2 Antibody (PACO54954)
- SKU:
- PACO54954
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | PTGR2 Antibody (PACO54954) |
| Antibody SKU: | PACO54954 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Prostaglandin reductase 2 protein (206-282AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate. All lanes: PTGR2 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39, 20 kDa. Observed band size: 39 kDa. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO54954 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO54954 at dilution of 1:100. |
| Background: | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-α and 15-keto-PGE2-α with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). |
| Synonyms: | Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1), PTGR2, ZADH1 |
| UniProt Protein Function: | PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.1.48; OxidoreductaseChromosomal Location of Human Ortholog: 14q24.3Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion bindingBiological Process: prostaglandin metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| UniProt Code: | Q8N8N7 |
| NCBI GenInfo Identifier: | 62901454 |
| NCBI Gene ID: | 145482 |
| NCBI Accession: | Q8N8N7.1 |
| UniProt Secondary Accession: | Q8N8N7,Q3L8A4, Q6MZH8 |
| UniProt Related Accession: | Q8N8N7 |
| Molecular Weight: | 19,675 Da |
| NCBI Full Name: | Prostaglandin reductase 2 |
| NCBI Synonym Full Names: | prostaglandin reductase 2 |
| NCBI Official Symbol: | PTGR2Â Â |
| NCBI Official Synonym Symbols: | PGR2; ZADH1; HEL-S-298Â Â |
| NCBI Protein Information: | prostaglandin reductase 2 |
| UniProt Protein Name: | Prostaglandin reductase 2 |
| UniProt Synonym Protein Names: | 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1 |
| Protein Family: | Prostaglandin reductase |
| UniProt Gene Name: | PTGR2Â Â |
| UniProt Entry Name: | PTGR2_HUMAN |
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