The PTGR2 Polyclonal Antibody (PAC05454) is a valuable tool for researchers studying the role of PTGR2 in cellular functions and disease processes. PTGR2, also known as prostaglandin reductase 2, is involved in the metabolism of prostaglandins and plays a critical role in the regulation of inflammation and oxidative stress.This antibody, generated in rabbits, has high specificity and sensitivity for PTGR2 in human samples, making it an ideal choice for Western blot applications. By binding to the PTGR2 protein, this antibody enables accurate detection and analysis of PTGR2 expression in a variety of cell types.
PTGR2 has been implicated in a range of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the molecular mechanisms of PTGR2 function is key to developing targeted therapies for these conditions. The PTGR2 Polyclonal Antibody is a valuable tool for investigating the role of PTGR2 in disease pathogenesis and identifying potential therapeutic targets.
Western Blot. Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate. All lanes: PTGR2 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39, 20 kDa. Observed band size: 39 kDa.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO54954 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO54954 at dilution of 1:100.
Background:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-α and 15-keto-PGE2-α with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.1.48; OxidoreductaseChromosomal Location of Human Ortholog: 14q24.3Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion bindingBiological Process: prostaglandin metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
