The PTGR2 Polyclonal Antibody (PACO22701) is a valuable tool for researchers studying PTGR2, a protein involved in various cellular processes, including oxidative stress response and lipid metabolism. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the PTGR2 protein, allowing for precise detection and analysis in a variety of cell types.PTGR2, also known as prostaglandin reductase 2, plays a crucial role in maintaining cellular homeostasis by regulating prostaglandin levels and lipid oxidation.
Its involvement in these processes makes it a potential target for research in areas such as cancer, cardiovascular diseases, and neurodegenerative disorders. Understanding the function of PTGR2 can provide insight into the underlying mechanisms of these diseases and aid in the development of targeted therapies.Overall, the PTGR2 Polyclonal Antibody (PACO22701) is a reliable tool for researchers seeking to investigate the role of PTGR2 in various cellular pathways and disease states, ultimately contributing to advancements in the fields of biochemistry and molecular biology.
Antibody Name:
PTGR2 Antibody (PACO22701)
Antibody SKU:
PACO22701
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human ZADH1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HUVEC cells, K562 cells and HT-29 cells, using ZADH1 antibody.
Background:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation By similarity.
PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.1.48; OxidoreductaseChromosomal Location of Human Ortholog: 14q24.3Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion bindingBiological Process: prostaglandin metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
