The PTGR2 Polyclonal Antibody (PAC011575) is a valuable tool for researchers studying PTGR2, a key enzyme involved in the metabolism of prostaglandins and leukotrienes. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot and immunohistochemistry applications. By binding to PTGR2, researchers can accurately detect and analyze the expression of this enzyme in various cell types, aiding in studies related to inflammation, oxidative stress, and cancer research.
PTGR2, also known as prostaglandin reductase 2, plays a crucial role in regulating the levels of pro-inflammatory lipid mediators, highlighting its importance in immune response modulation and tissue homeostasis. Dysregulation of PTGR2 has been implicated in various pathological conditions, making it a promising target for therapeutic interventions. By understanding the function of PTGR2, researchers can potentially develop novel strategies for treating inflammatory disorders, cancer, and other related diseases.
PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.1.48; OxidoreductaseChromosomal Location of Human Ortholog: 14q24.3Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion bindingBiological Process: prostaglandin metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
