The PTGR2 Polyclonal Antibody (PAC002495) is a valuable tool for researchers studying the PTGR2 protein, which is involved in the regulation of oxidative stress and inflammation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of PTGR2 expression in various cell types.PTGR2, also known as prostaglandin reductase 2, plays a crucial role in maintaining cellular redox balance and protecting cells from oxidative damage. Dysregulation of PTGR2 expression has been implicated in a variety of pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular disorders.
By studying the function of PTGR2, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for their treatment.Overall, the PTGR2 Polyclonal Antibody is a versatile tool for investigating the role of PTGR2 in health and disease, making it an essential reagent for studies in the fields of molecular biology, biochemistry, and medicine.
Antibody Name:
PTGR2 Antibody
Antibody SKU:
PACO02495
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human PTGR2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.1.48; OxidoreductaseChromosomal Location of Human Ortholog: 14q24.3Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion bindingBiological Process: prostaglandin metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
