PTGIS Antibody (PACO54950)
- SKU:
- PACO54950
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PTGIS Antibody (PACO54950)
The PTGIS Polyclonal Antibody (PACO54950) is a valuable tool for researchers studying the prostaglandin I2 synthase (PTGIS) protein. PTGIS is an enzyme involved in the production of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications, enabling the detection and analysis of PTGIS in various cell types.Prostacyclin plays a crucial role in cardiovascular health, as it helps maintain proper blood flow and prevents blood clots. Dysregulation of PTGIS and prostacyclin production has been implicated in several cardiovascular diseases, making PTGIS an attractive target for research.
This antibody provides researchers with a reliable tool to investigate the role of PTGIS in cardiovascular disorders and develop potential therapies targeting this pathway.Overall, the PACO54950 PTGIS Polyclonal Antibody is a valuable asset for studies in cardiovascular biology, vascular physiology, and drug development aimed at modulating prostacyclin levels for therapeutic purposes. Its specificity and sensitivity make it an essential reagent for researchers interested in understanding the complex role of PTGIS in health and disease.
| Antibody Name: | PTGIS Antibody (PACO54950) |
| Antibody SKU: | PACO54950 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Prostacyclin synthase protein (113-199AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO54950 at dilution of 1:100. |
| Background: | Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). |
| Synonyms: | Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase), PTGIS, CYP8 CYP8A1 |
| UniProt Protein Function: | PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus Molecular Function:protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16647 |
| NCBI GenInfo Identifier: | 2493373 |
| NCBI Gene ID: | 5740 |
| NCBI Accession: | Q16647.1 |
| UniProt Secondary Accession: | Q16647,Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4, |
| UniProt Related Accession: | Q16647 |
| Molecular Weight: | 57,104 Da |
| NCBI Full Name: | Prostacyclin synthase |
| NCBI Synonym Full Names: | prostaglandin I2 (prostacyclin) synthase |
| NCBI Official Symbol: | PTGISÂ Â |
| NCBI Official Synonym Symbols: | CYP8; PGIS; PTGI; CYP8A1Â Â |
| NCBI Protein Information: | prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase |
| UniProt Protein Name: | Prostacyclin synthase |
| UniProt Synonym Protein Names: | Prostaglandin I2 synthase |
| Protein Family: | Prostacyclin receptor |
| UniProt Gene Name: | PTGISÂ Â |
| UniProt Entry Name: | PTGIS_HUMAN |
| Antibodies | ELISA Kits |
| PTGIS Antibody (PACO04809) | Human PTGIS / Prostaglandin I Synthase ELISA Kit |
| Human PTGIS (Prostaglandin I Synthase) CLIA Kit (HUES01018) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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Human Prostacyclin Receptor (PTGIR) ELISA Kit (HUDL02445)
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