PTGIS Antibody (PACO22775)
- SKU:
- PACO22775
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PTGIS Antibody (PACO22775)
The PTGIS Polyclonal Antibody (PAC02775) is a valuable tool for research involving prostaglandin I2 synthase (PTGIS), an enzyme that plays a key role in the production of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. This antibody, generated in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It targets the PTGIS protein, allowing for accurate detection and analysis in various experimental settings.PTGIS is involved in multiple physiological processes, including vascular homeostasis, inflammation, and angiogenesis, making it a crucial target for investigation in cardiovascular diseases, hypertension, and thrombotic disorders.
By studying the function and regulation of PTGIS, researchers can gain insights into the pathways involved in these conditions and potentially identify new therapeutic targets for intervention.Overall, the PTGIS Polyclonal Antibody is a reliable tool for researchers interested in exploring the role of PTGIS in health and disease, providing valuable insights into the mechanisms underlying cardiovascular and inflammatory disorders.
| Antibody Name: | PTGIS Antibody (PACO22775) |
| Antibody SKU: | PACO22775 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from Internal of human PTGIS. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from K562 cells, using PTGIS antibody. |
| Background: | Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). |
| Synonyms: | CYP8; CYP8A1; cytochrome P450; family 8; subfamily A |
| UniProt Protein Function: | PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus Molecular Function:protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16647 |
| NCBI GenInfo Identifier: | 2493373 |
| NCBI Gene ID: | 5740 |
| NCBI Accession: | Q16647.1 |
| UniProt Secondary Accession: | Q16647,Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4, |
| UniProt Related Accession: | Q16647 |
| Molecular Weight: | 57,104 Da |
| NCBI Full Name: | Prostacyclin synthase |
| NCBI Synonym Full Names: | prostaglandin I2 (prostacyclin) synthase |
| NCBI Official Symbol: | PTGISÂ Â |
| NCBI Official Synonym Symbols: | CYP8; PGIS; PTGI; CYP8A1Â Â |
| NCBI Protein Information: | prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase |
| UniProt Protein Name: | Prostacyclin synthase |
| UniProt Synonym Protein Names: | Prostaglandin I2 synthase |
| Protein Family: | Prostacyclin receptor |
| UniProt Gene Name: | PTGISÂ Â |
| UniProt Entry Name: | PTGIS_HUMAN |
| Antibodies | ELISA Kits |
| PTGIS Antibody (PACO04809) | Human PTGIS / Prostaglandin I Synthase ELISA Kit |
| Human PTGIS (Prostaglandin I Synthase) CLIA Kit (HUES01018) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
PTGIS Antibody (PACO04809)
PTGIS Antibody (PACO54950)
Human Prostaglandin I Synthase (PTGIS) ELISA Kit (HUDL02446)
Rat PTGIS (Prostaglandin I Synthase) ELISA Kit (RTFI01269)
Human PTGIS / Prostaglandin I Synthase ELISA Kit (HUFI02802)
Human Prostacyclin Receptor (PTGIR) ELISA Kit (HUDL02445)
SPEF2 Antibody (PACO64977)
